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How It Works
Built-in near-field communication (NFC) reader enables you to pull up your custom protocols and results with a single tap, saving you precious time.
Easy-to-use touchscreen allows you to quickly set up your experiments, use preconfigured analysis methods, and view tutorial videos.
Superior optical system includes a xenon flash lamp and features an ultra-cooled photomultiplier tube (PMT) to -5°C for excellent sensitivity.
Optional SmartInject™ system enables you to expand your lab’s capabilities to include flash applications such as dual luciferase and ATP assays.
QuickSync technology automatically delivers data to workstations, eliminating the need to retrieve data directly from the instrument.
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Cell approaching the nozzle
Cell ejected from the nozzle
Cell detected at the nozzle
Obtain instantaneous evidence of monoclonality
A high resolution and large depth-of-field camera is used to capture a time-sequence of 5 images as a single cell is deposited into the well. Not only does this ensures that cells are in focus over 99% of time, but also minimizes concerns of monoclonality by monitoring the single-cell environment for events that may be missed with a single snapshot.
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Replay Animation
The system continues to eject and deflect droplets until a droplet containing a single cell is detected.
The droplet is ejected and immediately deflected into waste.
The vacuum is activated.
ON
OFF
Debris
The system can recognize and sort cells based on size and morphology. Hence, debris/dead cell can be recognized independently.
Debris Event
Detected:
Vacuum:
Vacuum
Microwell
Cartridge
Cell Suspension
6
Replay Animation
The system continues to eject and deflect droplets until a droplet containing a single cell is detected.
The droplet is ejected and immediately deflected into waste.
OFF
ON
Vacuum is activated.
0 cell
No cells are detected in the nozzle.
Zero Cell Event
Detected:
Vacuum:
Vacuum
Microwell
Cartridge
Cell Suspension
5
Replay Animation
The system continues to eject and dispose of droplets until a droplet containing a single cell is detected.
The droplet with >1 cell is ejected and immediately vacuumed into the waste.
This activates the vacuum.
ON
OFF
>1 cell
Detected:
Vacuum:
Multi-Cell Event
The system detects >1 cell in the nozzle.
Vacuum
Microwell
Cartridge
Cell Suspension
4
Replay Animation
A single cell has been dispensed into the well successfully. The nozzle is positioned over the next well until another single cell is detected.
The cell lands in the dedicated well.
A droplet containing a single cell is ejected while the vacuum is shut.
1 cell
Detected:
Vacuum:
OFF
The system detects and images a single cell approaching the nozzle.
Single Cell Event
Vacuum
Microwell
Cartridge
Cell Suspension
3
The core of the single cell printing technology lies in the disposable cartridge and high-resolution camera.
2
The cell-containing sample is pipetted into the printing cartridge, where an external piezo-driven actuator is used to eject cell-containing droplets out of the cartridge nozzle. The camera captures a sequence of events to determine the cell number in each droplet.
Nozzle
Cartridge
The CloneSelect™ Single-Cell Printer™ utilizes a patented, microfluidics-based single cell printing technology--similar to an inkjet printer--and cellular imaging to automatically sort and deposit single cells into standard 96- and 384-well microplates.
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